These studies demonstrated that fasting upregulates the plasma membrane OCTN2 carnitine transporter in the liver, heart, kidneys and in rats with strong caloric restriction, additionally in skeletal muscle [111]
Disadvantages: The effects may vary depending on the individual characteristics of the organism
the synergy is plausible and clinically observed, but not yet formally proven
Another study of the same group further demonstrated the cytotoxic in vitro effect of gemigliptin in TC cells also showing an increase in its cytotoxic activity when combined with one histone deacetylase inhibitor (PXD101) (Kim et al., 2018b)
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